ParkinsonCanadaV1, Main, Exploration, bibRecord, 003824

Expression of glial cell line-derived neurotrophic factor and its mRNA in the nigrostriatal pathway following MPTP treatment

Identifieur interne : 003824 ( Main/Exploration ); précédent : 003823; suivant : 003825

Expression of glial cell line-derived neurotrophic factor and its mRNA in the nigrostriatal pathway following MPTP treatment

Auteurs : T. Inoue [Canada, Japon] ; J. Tsui [Canada] ; N. Wong [Canada] ; SHIN YI WONG [Canada] ; F. Suzuki [Japon] ; YIN NAM KWOK [Canada]

Source :

Brain research [ 0006-8993 ] ; 1999.

RBID : Pascal:99-0254765

Descripteurs français

Pascal (Inist)
- Corps strié, Expression génique, Facteur GDNF, Facteur neurotrophique, Voie nigrostriatale, Neurotoxine, Parkinson maladie, Pathologie expérimentale, Animal, Souris, MPTP.

English descriptors

KwdEn :
- Animal, Corpus striatum, Experimental disease, Gene expression, Glial cell line derived neurotrophic factor, Mouse, Neurotoxin, Neurotrophic factor, Nigrostriatal pathway, Parkinson disease.

Abstract

Striatal glial cell line-derived neurotrophic factor (GDNF) mRNA levels in both young (2-month old) and old (11-month old) C57BL/6J mice were quantified at 3, 7 and 21 days following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridin (MPTP) treatment. MPTP did not alter the expression of GDNF mRNA in these animals. Immunoreactive staining of GDNF in the substantia nigra and the striatum was also unchanged. In conclusion, MPTP-induced dopaminergic neurotoxicity does not elicit any changes in the expression of endogenous GDNF or its mRNA in the adult mouse brain.

Affiliations:

Canada, Japon

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000D70
to stream PascalFrancis, to step Curation: 001153
to stream PascalFrancis, to step Checkpoint: 000C56
to stream Main, to step Merge: 003E09
to stream Main, to step Curation: 003824

Le document en format XML

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<term>Neurotoxin</term>
<term>Neurotrophic factor</term>
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<term>Neurotoxine</term>
<term>Parkinson maladie</term>
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<front><div type="abstract" xml:lang="en">Striatal glial cell line-derived neurotrophic factor (GDNF) mRNA levels in both young (2-month old) and old (11-month old) C57BL/6J mice were quantified at 3, 7 and 21 days following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridin (MPTP) treatment. MPTP did not alter the expression of GDNF mRNA in these animals. Immunoreactive staining of GDNF in the substantia nigra and the striatum was also unchanged. In conclusion, MPTP-induced dopaminergic neurotoxicity does not elicit any changes in the expression of endogenous GDNF or its mRNA in the adult mouse brain.</div>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Expression of glial cell line-derived neurotrophic factor and its mRNA in the nigrostriatal pathway following MPTP treatment

Expression of glial cell line-derived neurotrophic factor and its mRNA in the nigrostriatal pathway following MPTP treatment

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri